The present manuscript describe simple, sensitive, rapid, accurate, precise and economical Q-absorbance method for the simultaneous determination of ciprofloxacin HCl and bromhexine HCl in their combined pharmaceutical dosage form. Absorbance ratio method uses the ratio of absorbance at two selected wavelengths, one which is an isoabsorptive point at 256 nm in methanol. The second wavelength is used 279 nm, which is λmax of ciprofloxacin HCl in Methanol. Linearity was observed for ciprofloxacin HCl and for bromhexine HCl in the concentration range of 2-12 μg/ml and (r2 = 0.999) and 5-30 μg/ml and (r2 = 0.993). The concentration of drugs was determined by using ratio of absorbance at isoabsorptive point and at the λmax of ciprofloxacin HCl. The method was successfully applied to pharmaceutical dosage form because of no interference. The result of analysis has been validated by recovery studies.
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